Amaro-Gahete, Francisco JJurado-Fasoli, LucasSanchez-Delgado, GuillermoGarcía-Lario, José VCastillo, Manuel JRuiz, Jonatan R2023-02-082023-02-082020-01-20http://hdl.handle.net/10668/14970This cross-sectional study investigates the relationship between the shed form of the Klotho protein (S-Klotho) in plasma, and cardiometabolic risk in healthy, sedentary adults. The study subjects were 214 healthy, sedentary adults (~64% women). Data were collected during the baseline assessments of two randomized controlled trials: The FIT-AGEING study (n=74 [~50% women] middle-aged adults aged 40-65 years) and the ACTIBATE study (n=140 [~70% women] young adults aged 18-25 years). A sex-specific cardiometabolic risk score was calculated for each subject based on waist circumference, systolic and diastolic blood pressure, and plasma glucose, high-density lipoprotein cholesterol and triglycerides. A significant inverse relationship was detected between S-Klotho and the cardiometabolic risk score of both the middle-aged men and women (β=-0.658, R2=0.433, P0.5), nor for the young, healthy men and women when analysed separately (all P>0.1). In conclusion, in healthy, sedentary, middle-aged adults, but not in young, healthy, sedentary adults, higher plasma S-Klotho concentrations are associated with a lower cardiometabolic risk score.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/agingbiomarkercholesterolglucoseinsulin sensitivityAdolescentAdultCardiovascular DiseasesCross-Sectional StudiesFemaleGene Expression RegulationGlucuronidaseHumansKlotho ProteinsMaleMetabolic DiseasesRisk FactorsSedentary BehaviorYoung Adultresearch article31958773open access10.18632/aging.1027711945-4589PMC7041759https://doi.org/10.18632/aging.102771https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041759/pdf