López Casado, Miguel ÁngelLorite, PedroPonce de León, CandelariaPalomeque, TeresaTorres, Maria Isabel2023-01-252023-01-252018-08-25http://hdl.handle.net/10668/12887Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Celiac disease exemplifies how an illness can have autoimmune-like features having to be driven by exogenous antigen and how can be reasonably considered as a model of organ-specific autoimmunity.enAutoantibodiesAutoimmunityCeliac diseaseImmune toleranceAnimalsAutoantibodiesAutoantigensAutoimmunityCeliac DiseaseDisease Models, AnimalGlutensHumansIntestinesMajor Histocompatibility Complexresearch article30167716open access10.1007/s00005-018-0520-z1661-4917https://link.springer.com/content/pdf/10.1007/s00005-018-0520-z.pdf