Díaz-Castro, JavierFlorido, JesusKajarabille, NaroaPrados, Soniade Paco, CatalinaOcon, OlgaPulido-Moran, MarioOchoa, Julio J2016-12-122016-12-122015Díaz-Castro J, Florido J, Kajarabille N, Prados S, de Paco C, Ocon O, et al. A new approach to oxidative stress and inflammatory signaling during labour in healthy mothers and neonates. Oxid Med Cell Longev. 2015;178536http://hdl.handle.net/10668/2567Journal Article;The objective of the current study was to investigate for the first time and simultaneously the oxidative stress and inflammatory signaling induced during the delivery in healthy mothers and their neonates. 56 mothers with normal gestational course and spontaneous delivery were selected. Blood samples were taken from mother (before and after delivery) both from vein and artery of umbilical cord. Lower antioxidant enzymes activities were observed in neonates compared with their mothers and lower oxidative stress in umbilical cord artery with respect to vein. There was an overexpression of inflammatory cytokines in the mother, such as IL-6 and TNF-α, and, in addition, PGE2 was also increased. Neonates showed lower levels of IL-6 and TNF-α and higher values of sTNF-RII and PGE2 in comparison with their mothers. Parturition increases oxidative damage in the mother, although the indicators of oxidative damage were lower in umbilical cord artery with respect to umbilical vein. The overexpression of inflammatory cytokines reveals that fetus suffers its own inflammatory process during parturition.enCatalasaDinoprostonaFemeninoSangre fetalEdad gestacionalGlutatión peroxidasaHumanosRecién nacidoInterleucina-6Trabajo de partoMadresEstrés oxidativoTransducción de señalSuperóxido dismutasaFactor de necrosis tumoral alfaMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::CatalaseMedical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators::Autacoids::Eicosanoids::Prostaglandins::Prostaglandins E::DinoprostoneMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Anatomy::Fluids and Secretions::Body Fluids::Blood::Fetal BloodMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Gestational AgeMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Glutathione PeroxidaseMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Named Groups::Persons::Age Groups::Infant::Infant, NewbornMedical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy::Labor, ObstetricMedical Subject Headings::Named Groups::Persons::Parents::MothersMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative StressMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative StressMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal TransductionMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Superoxide DismutaseMedical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpharesearch article25722791open access10.1155/2015/1785361942-0994PMC4333327