Ávalos-Moreno, MartaLópez-Tejada, AraceliBlaya-Cánovas, Jose L.Cara-Lupiañez, Francisca E.González-González, AdriánLorente, Jose A.Sánchez-Rovira, PedroGranados-Principal, Sergio2022-06-202022-06-202020-10-29Avalos-Moreno M, López-Tejada A, Blaya-Cánovas JL, Cara-Lupiañez FE, González-González A, Lorente JA, et al. Drug Repurposing for Triple-Negative Breast Cancer. J Pers Med. 2020 Oct 29;10(4):200http://hdl.handle.net/10668/3692Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer which presents a high rate of relapse, metastasis, and mortality. Nowadays, the absence of approved specific targeted therapies to eradicate TNBC remains one of the main challenges in clinical practice. Drug discovery is a long and costly process that can be dramatically improved by drug repurposing, which identifies new uses for existing drugs, both approved and investigational. Drug repositioning benefits from improvements in computational methods related to chemoinformatics, genomics, and systems biology. To the best of our knowledge, we propose a novel and inclusive classification of those approaches whereby drug repurposing can be achieved in silico: structure-based, transcriptional signatures-based, biological networks-based, and data-mining-based drug repositioning. This review specially emphasizes the most relevant research, both at preclinical and clinical settings, aimed at repurposing pre-existing drugs to treat TNBC on the basis of molecular mechanisms and signaling pathways such as androgen receptor, adrenergic receptor, STAT3, nitric oxide synthase, or AXL. Finally, because of the ability and relevance of cancer stem cells (CSCs) to drive tumor aggressiveness and poor clinical outcome, we also focus on those molecules repurposed to specifically target this cell population to tackle recurrence and metastases associated with the progression of TNBC.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Triple-negative breast cancerPersonalized medicineComputational methodsDrug repurposingClinical trialsCancer stem cellsNeoplasias de la mama triple negativasMedicina de precisiónReposicionamiento de medicamentosEnsayos clínicos como asuntoCélulas madre neoplásicasMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms::Triple Negative Breast NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug Discovery::Drug RepositioningMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as TopicMedical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem CellsMedical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Drugs, InvestigationalMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Systems BiologyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug DiscoveryMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal TransductionMedical Subject Headings::Information Science::Information Science::Medical Informatics::Medical Informatics Applications::Information Storage and Retrieval::Data MiningMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrencereview article33138097open access10.3390/jpm100402002075-4426PMC7711505