Esteras, RaquelFox, Jonathan GGeddes, Colin CMackinnon, BruceOrtiz, AlbertoMoreno, Juan Antonio2025-01-072025-01-072020-07-07Esteras R, Fox JG, Geddes CC, Mackinnon B, Ortiz A, Moreno JA. Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis. J Clin Med. 2020 Jul 7;9(7):21352077-0383https://hdl.handle.net/10668/28317Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-proven ATIN was conducted. Results: Haematuria was present in 66 (60%) ATIN patients. A higher percentage of ATIN patients with haematuria had proteinuria than patients without haematuria (89.4% vs. 59.1%, p = 0.001) with significantly higher levels of proteinuria (median (interquartile range) protein:creatinine ratio 902.70 (513-1492) vs. 341.00 (177-734) mg/g, pp <0.001). Moreover, those patients with more haematuria intensity had a higher urinary protein:creatinine ratio (1352.65 (665–2292) vs. 849.60 (562–1155) mg/g, p = 0.02). Those patients with higher proteinuria were more likely to need renal replacement therapy (22.7 vs. 0%, p = 0.03) and to suffer relapse (4 vs. 0%, p = 0.03). At the end of follow up, haematuric ATIN patients had higher serum creatinine levels (3.19 ± 2.91 vs. 1.91 ± 1.17 mg/dL, p = 0.007), and a trend towards a higher need for acute dialysis (7 vs. 1%, p = 0.09) and renal replacement therapy (12.1 vs. 2.3%, p = 0.12). Haematuria is common in ATIN and it is associated with worse renal function outcomes.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/acute kidney injuryacute tubulointerstitial nephritischronic kidney diseasehaematuriakidney biopsyoutcomesproteinuriaCreatinineRenal DialysisHematuriaNephritis, InterstitialRenal Replacement Therapyresearch article32645825open accessNefritis tubulointersticialHematuriaProteinuriaInsuficiencia renal agudaTerapia de reemplazo renalCreatinina sérica10.3390/jcm9072135PMC7408949https://www.mdpi.com/2077-0383/9/7/2135/pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7408949/pdf