Bendala Estrada, Alejandro DavidCalderon Parra, JorgeFernandez Carracedo, EduardoMuino Miguez, AntonioRamos Martinez, AntonioMunez Rubio, ElenaRubio-Rivas, ManuelAgudo, PalomaArnalich Fernandez, FranciscoEstrada Perez, VicenteTaboada Martinez, Maria LuisaCrestelo Vieitez, AnxelaPesqueira Fontan, Paula MariaBustamante, MartaFreire, Santiago J.Oriol-Bermudez, IsabelArtero, ArturoOlalla Sierra, JulianAreses Manrique, MariaJavier Carrasco-Sanchez, H. FranciscoCarolina Vento, VanessaGarcia Garcia, Gema MariaCubero-Morais, PabloCasas-Rojo, Jose-ManuelMillan Nunez-Cortes, Jesus2025-01-072025-01-072021-11-08https://hdl.handle.net/10668/26563Background Since December 2019, the COVID-19 pandemic has changed the concept of medicine. This work aims to analyze the use of antibiotics in patients admitted to the hospital due to SARS-CoV-2 infection. Methods This work analyzes the use and effectiveness of antibiotics in hospitalized patients with COVID-19 based on data from the SEMI-COVID-19 registry, an initiative to generate knowledge about this disease using data from electronic medical records. Our primary endpoint was all-cause in-hospital mortality according to antibiotic use. The secondary endpoint was the effect of macrolides on mortality. Results Of 13,932 patients, antibiotics were used in 12,238. The overall death rate was 20.7% and higher among those taking antibiotics (87.8%). Higher mortality was observed with use of all antibiotics (OR 1.40, 95% CI 1.21-1.62; penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2AntibioticsSurvivalMacrolidesAzithromycinBacterial coinfectionInfluenzaInfectionAdultsSars-cov-2GuidelinePneumoniaVirusresearch article34749645open access10.1186/s12879-021-06821-11471-2334https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/s12879-021-06821-1715771300004