Santamaria-Martos, FernandoBenítez, IvanGirón, CristinaBarbé, FerranMartínez-García, Miguel-AngelHernández, LuisMontserrat, Josep MNagore, EduardoMartorell, AntonioCampos-Rodriguez, FranciscoCorral, JaimeCabriada, ValentinAbad, JorgeMediano, OlgaTroncoso, Maria FCano-Pumarega, IreneFortuna Gutierrez, Ana MariaDiaz-Cambriles, TrinidadSomoza-Gonzalez, MariaAlmendros, IsaacFarre, RamonGozal, DavidSánchez-de-la-Torre, ManuelSpanish Sleep Network2023-01-252023-01-252018-03-15http://hdl.handle.net/10668/12221The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma.This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI) 0-5 events·h-1), mild OSA (AHI 5-15 events·h-1) and moderate-severe OSA (AHI >15 events·h-1). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable.360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8-68.0) years and AHI 8.55 (2.8-19.5) events·h-1). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion.enAdultAgedBiomarkers, TumorCarcinogenesisEnzyme-Linked Immunosorbent AssayFemaleHumansHypoxiaIntercellular Adhesion Molecule-1Interleukin-8MaleMelanomaMiddle AgedS100 Calcium Binding Protein beta SubunitSkin NeoplasmsSleep Apnea, ObstructiveVascular Cell Adhesion Molecule-1Vascular Endothelial Growth Factor Aresearch article29519923open access10.1183/13993003.01885-20171399-3003https://erj.ersjournals.com/content/erj/51/3/1701885.full.pdf