Lopez-Pais, JavierIzquierdo Coronel, BárbaraRaposeiras-Roubín, SergioÁlvarez Rodriguez, LeyreVedia, OscarAlmendro-Delia, ManuelSionis, AlessandroMartin-Garcia, Agustin CUribarri, AitorBlanco, EmiliaMartín de Miguel, IreneAbu-Assi, EmadGalán Gil, DavidSestayo Fernández, ManuelaEspinosa Pascual, Maria JesúsAgra-Bermejo, Rosa MaríaLópez Otero, DiegoGarcía Acuña, Jose MaríaAlonso Martín, Joaquín JesúsGonzalez-Juanatey, Jose RamónPerez de Juan Romero, Miguel ÁngelNúñez-Gil, Iván J2023-05-032023-05-032022-03-142297-055Xhttp://hdl.handle.net/10668/20543Whether Takotsubo syndrome (TTS) should be classified within myocardial infarction with non-obstructive coronary arteries (MINOCAs) is still controversial. The aim of this work was to evaluate the main differences between TTS and non-TTS MINOCAs. A cohort study based on two prospective registries: TTS from the RETAKO registry (N:1,015) and patients with non-TTS MINOCAs from contemporary records of acute myocardial infarction from five 5 national centers (N:1,080). Definitions and management recommended by the ESC were used. Survival analysis was based on the Cox regression analysis; propensity score matching (PS) was created to adjust prognostic variables. Takotsubo syndrome were more often women (85.9 vs. 51.9%; p Compared to the rest of MINOCAs, TTS presents a different patient profile and a more aggressive acute phase. However, its long-term cardiovascular prognosis is better. These results support that TTS should be considered a separate entity with unique characteristics and prognosis.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/MINOCATakotsubodefinitionprognosisworking diagnosisresearch article35360039open access10.3389/fcvm.2022.742010PMC8964136https://www.frontiersin.org/articles/10.3389/fcvm.2022.742010/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964136/pdf