Jurado-Garcia, AntonioMolina-Recio, GuillermoFeu-Collado, NuriaPalomares-Muriana, AnaGomez-Gonzalez, Adela MariaMarquez-Perez, Francisca LourdesJurado-Gamez, Bernabe2023-02-092023-02-092020-08-26Jurado-García A, Molina-Recio G, Feu-Collado N, Palomares-Muriana A, Gómez-González AM, Márquez-Pérez FL, et al. Effect of a Graduated Walking Program on the Severity of Obstructive Sleep Apnea Syndrome. A Randomized Clinical Trial. Int J Environ Res Public Health. 2020 Aug 31;17(17):6334http://hdl.handle.net/10668/16195Obstructive sleep apnea syndrome (OSAS) is a common disease. The objective of this research was to determine the effectiveness of a graduated walking program in reducing the apnea-hypopnea index number in patients with obstructive sleep apnea syndrome (OSAS). A randomized controlled clinical trial with a two-arm parallel in three tertiary hospitals was carried out with seventy sedentary patients with moderate to severe OSAS. Twenty-nine subjects in each arm were analyzed by protocol. The control group received usual care, while usual care and an exercise program based on progressive walks without direct supervision for 6 months were offered to the intervention group. The apnea-hypopnea index decreased by six points in the intervention group, and improvements in oxygen desaturation index, total cholesterol, and Low-Density Lipoprotein of Cholesterol (LDL-c) were observed. A higher decrease in sleep apnea-hypopnea index (45 ± 20.6 vs. 34 ± 26.3/h; p = 0.002) was found in patients with severe vs. moderate OSAS, as well as in oxygen desaturation index from baseline values (43.3 vs. 34.3/h; p = 0.046). Besides, High-Density Lipoprotein of Cholesterol (HDL-c) values showed a higher increase in the intervention group (45.3 vs. 49.5 mg/dL; p = 0.009) and also, a higher decrease in LDL-c was found in this group (141.2 vs. 127.5 mg/dL; p = 0.038). A home physical exercise program is a useful and viable therapeutic measure for the management of OSAS.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cardiovascular diseasesExercise and pulmonary rehabilitationPhysical activitySleep apneaCholesterolCholesterol, HDLExercise therapyFemaleHumansMaleMiddle agedSleepSleep apnea, obstructiveWalkingresearch article32878112open accessColesterolHDL-colesterolSueñoSíndromes de la apnea del sueñoTerapia por ejercicio10.3390/ijerph171763341660-4601PMC7503647https://www.mdpi.com/1660-4601/17/17/6334/pdf?version=1598952460https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503647/pdf