Faura, JúliaRamiro, LauraSimats, AlbaMa, FeifeiPenalba, AnnaGasull, TeresaRosell, AnnaMontaner, JoanBustamante, Alejandro2023-05-032023-05-032022-07-22http://hdl.handle.net/10668/21178After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. We performed transient middle cerebral artery occlusion (MCAO) and sham surgery on C57BL/6J mice and collected bronchoalveolar lavage fluid (BALF), serum, brain, and lung homogenate samples 24 h after surgery. A 92 proteins-panel developed by Olink Proteomics® was used to analyze the content in BALF and lung homogenates. MCAO animals had higher protein concentration levels in BALF than sham-controls, but these levels did not correlate with the infarct volume. No alteration in alveolar-capillary barrier permeability was observed. A total of 12 and 14 proteins were differentially expressed between the groups (FDRenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/inflammationpulmonary complicationsstrokeAnimalsBrain IschemiaDisease Models, AnimalInfarction, Middle Cerebral ArteryLungMiceMice, Inbred C57BLStrokeTransforming Growth Factor alpharesearch article35897671open access10.3390/ijms231580931422-0067PMC9329771https://www.mdpi.com/1422-0067/23/15/8093/pdf?version=1658492939https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329771/pdf