Casas, RosaUrpi-Sarda, MireiaSacanella, EmilioArranz, SaraCorella, DoloresCastaner, OlgaLamuela-Raventos, Rosa-MariaSalas-Salvado, JordiLapetra, JosePortillo, Maria P.Estruch, Ramon2023-02-122023-02-122017-01-010962-9351http://hdl.handle.net/10668/19055Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex (R). Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1 beta (PenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Low-grade inflammationCardiovascular-diseaseHigh-riskMarkersAtherosclerosisActivationCytokinesPatternresearch articleopen access10.1155/2017/36743901466-1861http://downloads.hindawi.com/journals/mi/2017/3674390.pdf399496900001