Aguareles, JoséParaíso-Luna, JuanPalomares, BelénBajo-Grañeras, RaquelNavarrete, CarmenRuiz-Calvo, AndreaGarcía-Rincón, DanielGarcía-Taboada, ElenaGuzmán, ManuelMuñoz, EduardoGalve-Roperh, Ismael2020-07-242020-07-242019-03-08Aguareles J, Paraíso-Luna J, Palomares B, Bajo-Grañeras R, Navarrete C, Ruiz-Calvo A, et al. Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration. Transl Neurodegener. 2019 Mar 8;8:9.http://hdl.handle.net/10668/3148The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by CB1 receptors, which can elicit psychotropic effects, but other targets devoid of psychotropic activity, including CB2 and nuclear PPARγ receptors, can also be the target of specific cannabinoids.enCannabinoidHuntingtinNeurodegenerationNeurogenesisPPARCannabinoidesProteína huntingtinaEnfermedades neurodegenerativasNeurodegenerative diseasesNeurogénesisPeroxisome proliferator-activated receptorsReceptores activados del proliferador del peroxisomaMedical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative DiseasesMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::CannabinoidsMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::NeurogenesisMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated ReceptorsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansresearch article30899454open access10.1186/s40035-019-0148-x2047-9158PMC6407204