Villatoro, Antonio JFernández, VivianaClaros, SilviaAlcoholado, CristinaCifuentes, ManuelMerayo-Lloves, JesúsAndrades, José ABecerra, José2023-01-252023-01-252017-10-28http://hdl.handle.net/10668/11803Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with significant limitations. Therefore, the latest research is focused on the development of new biological strategies, with the aim of regenerating affected tissues, or at least restricting the progression of the disease, reducing scar tissue, and maintaining corneal transparency. Therapies range from growth factors and cytokines to the use of different cell sources, in particular mesenchymal stem cells, due to their multipotentiality, trophic, and immunomodulatory properties. We will review the state of the art and the latest advances and results of these promising treatments in this pathology.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/allogenic cell therapydry eyegrowth factorkeratoconjunctivitis siccalacrimal glandmesenchymal stem cellregenerative medicineAnimalsCell- and Tissue-Based TherapyDry Eye SyndromesHumansIntercellular Signaling Peptides and ProteinsRegenerative MedicineStem Cell TransplantationStem Cellsresearch article29143779open access10.3390/ijms181122641422-0067PMC5713234https://www.mdpi.com/1422-0067/18/11/2264/pdf?version=1509183548https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713234/pdf