Gimenez-Miranda, LuisBeltran-Romero, LuisLeon-Jimenez, DavidStiefel, Pablo2025-01-072025-01-072021-11-161524-6175https://hdl.handle.net/10668/27797SARS-CoV-2 is causing devastation both in human lives and economic resources. When the world seems to start overcoming the pandemics scourge, the threat of long-term complications of COVID-19 is rising. Reports show that some of these long-term effects may contribute to the main cause of morbimortality worldwide: the vascular diseases. Given the evidence of damage in the endothelial cells due to SARS-CoV-2 and that endothelial dysfunction precedes the development of arteriosclerosis, the authors propose to measure endothelial function around 6-12 months after acute disease in hypertensive patients, especially if they have other cardiovascular risk factors or overt vascular disease. The methods the authors propose are cost-effective and can be made available to any hypertension unit. These methods could be the "in vivo" assessment of endothelial function by flow mediated vasodilatation after ischemia by Laser-Doppler flowmetry and the measurement of plasma free circulating DNA and microparticles of endothelial origin.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/circulating free DNAendothelial dysfunctionendothelial microparticlesLaser-Doppler flowmetrySARS CoV-2Cell-free dnaPreeclampsiaDysfunctionCorrelateresearch article34786820open access10.1111/jch.143761751-7176https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jch.14376719267800001