Wellinger, Ralf Erik2023-01-252023-01-252018-12-28http://hdl.handle.net/10668/13361Genomic DNA can be prone to endogenous nicks. The contribution of DNA nicks to genome instability includes the breakage of double-stranded DNA due to single-stranded DNA nicking. A recent study mapped the genome-wide distribution of endogenous DNA nicks suggesting that transcription contributes to the formation and distribution of DNA nicks. R-loops are a byproduct of transcription, and nicked DNA seems to contribute to R-loop formation and vice versa. Here, I want discuss the possibility that the 3'OH of nicked DNA at R-loops could trigger unscheduled replication events.enDNA nickDNA replicationR-loopDNA Breaks, Single-StrandedDNA RepairDNA, Single-StrandedRNA Polymerase IISaccharomyces cerevisiaeresearch article30590979open access10.1080/15384101.2018.15588611551-4005PMC6343732https://www.tandfonline.com/doi/pdf/10.1080/15384101.2018.1558861?needAccess=truehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343732/pdf