Sánchez-González, José-MaríaRocha-de-Lossada, CarlosBorroni, DavideDe-Hita-Cantalejo, ConcepciónAlonso-Aliste, Federico2023-05-032023-05-032022http://hdl.handle.net/10668/21627To analyze the efficacy, safety, predictability, and stability in myopic and astigmatic small-incision lenticule extraction (SMILE) with simultaneous prophylactic corneal crosslinking (CXL) in thin corneas. A total of 48 eyes from 24 patients who underwent myopic and astigmatism SMILE with simultaneous prophylactic CXL were included in this retrospective study. All patients had a 24-month follow-up. A femtosecond laser was performed with VisuMax (Carl Zeiss Meditec). CXL treatment was applied when the predicted stromal thickness was less than 330 μm. The patients' mean age was 31.58 ± 6.23 years. The previous mean spherical equivalent was - 6.85 ± 1.80 (-9.75 to - 2.00) D. The postoperative mean spherical equivalent was - 0.50 ± 0.26 (-1.00 to + 0.25) D; 60% of the eyes had 20/20 or better; 19% lost one line; 58% were within ± 0.50 D; and 8.3% of the eyes changed 0.50 D or more between 3 and 24 months. Prophylactic CXL with simultaneous SMILE for myopia and astigmatism femtosecond laser surgery technique appears to be partially effective, safe, predictable, and stable after 24 months of follow-up.enAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Corneal crosslinkingSMILEXTRArefractive surgerysmall incision lenticule extractionAdultAstigmatismCorneaCorneal StromaCorneal Surgery, LaserHumansLasers, ExcimerMyopiaRefraction, OcularRetrospective StudiesTreatment Outcomeresearch article34937212open access10.4103/ijo.IJO_810_211998-3689PMC8917579https://doi.org/10.4103/ijo.ijo_810_21https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917579/pdf