Carrasco, FranciscoAnguita, ManuelRuiz, MartínCastillo, Juan CarlosDelgado, MónicaMesa, DoloresRomo, EliasPan, ManuelSuárez de Lezo, Jose2023-01-252023-01-252015-12-24http://hdl.handle.net/10668/9682Use of cardiac pacing devices has grown in recent years. Our aim was to evaluate changes in epidemiology and clinical features of infective endocarditis (IE) involving pacemaker devices in a large series of IE over the last 27 years (1987-2013). From 1987 to December 2013, 413 consecutive IE cases were diagnosed in our hospital. During this period, 7424 pacemaker devices were implanted (6917 pacemakers, 239 implantable cardiac defibrillators, 158 resynchronization devices, and 110 resynchronization/defibrillator devices). All consecutive cases of IE on pacemaker devices were included and analysed. Infective endocarditis on pacemaker devices represented 6.1% of all endocarditis cases (25 patients), affecting 3.6/1000 of all implanted pacemakers. Its proportion increased from 1.25% of all endocarditis in 1987-1993 to 4.08% in 1994-2000, 7.69% in 2001-2007 and 9.32% in 2008-2013 (P Infective endocarditis on pacemaker devices has shown an increasing incidence during the past decades, representing almost 10% of all IE in the last 6 years. This is a severe disease, with a high rate of severe complications and requiring removal of device in most cases. In spite of therapy, early mortality is high.enCardiac resynchronization therapyDeviceEndocarditisImplantable cardioverter-defibrillatorInfective endocarditisPacemakerAgedAged, 80 and overAnti-Bacterial AgentsDefibrillators, ImplantableDevice RemovalEndocarditis, BacterialFemaleHeart FailureHumansMaleMiddle AgedPacemaker, ArtificialProsthesis-Related InfectionsSpainresearch article26705558open access10.1093/europace/euv3771532-2092https://academic.oup.com/europace/article-pdf/18/6/836/7471479/euv377.pdf