Nedeljkovic, IvanaLahousse, LiesCarnero-Montoro, ElenaFaiz, AlenVonk, Judith Mde Jong, Kimvan der Plaat, Diana Avan Diemen, Cleo Cvan den Berge, MaartenObeidat, Ma'enBossé, YohanNickle, David CConsortium, B I O SUitterlinden, Andre Gvan Meurs, Joyce B JStricker, Bruno H CBrusselle, Guy GPostma, Dirkje SBoezen, H Marikevan Duijn, Cornelia MAmin, Najaf2023-01-252023-01-252018http://hdl.handle.net/10668/11759Chronic obstructive pulmonary disease (COPD) is among the major health burdens in adults. While cigarette smoking is the leading risk factor, a growing number of genetic variations have been discovered to influence disease susceptibility. Epigenetic modifications may mediate the response of the genome to smoking and regulate gene expression. Chromosome 19q13.2 region is associated with both smoking and COPD, yet its functional role is unclear. Our study aimed to determine whether rs7937 (RAB4B, EGLN2), a top genetic variant in 19q13.2 region identified in genome-wide association studies of COPD, is associated with differential DNA methylation in blood (N = 1490) and gene expression in blood (N = 721) and lungs (N = 1087). We combined genetic and epigenetic data from the Rotterdam Study (RS) to perform the epigenome-wide association analysis of rs7937. Further, we used genetic and transcriptomic data from blood (RS) and from lung tissue (Lung expression quantitative trait loci mapping study), to perform the transcriptome-wide association study of rs7937. Rs7937 was significantly (FDR enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/AdultAgedChromosome MappingChromosomes, Human, Pair 19DNA MethylationEpigenesis, GeneticFemaleGene ExpressionGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansHypoxia-Inducible Factor-Proline DioxygenasesMaleMiddle AgedPolymorphism, Single NucleotidePulmonary Disease, Chronic ObstructiveQuantitative Trait LociSmokingrab4 GTP-Binding Proteinsresearch article29092026open access10.1093/hmg/ddx3901460-2083PMC5886099https://academic.oup.com/hmg/article-pdf/27/2/396/24325580/ddx390.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886099/pdf