Gómez-González, BelénAguilera, Andrés2023-01-252023-01-252019-05-23http://hdl.handle.net/10668/14011Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. Thus, transcription can become a potentially hazardous process promoting localized replication fork hindrance and stress, which would ultimately cause genome instability, a hallmark of cancer cells. Understanding the causes behind transcription-replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/DNA–RNA hybridschromosome fragilitygenetic instabilityreplication fork stallingtranscriptionDNA ReplicationGenomeGenomic InstabilityHumansNeoplasmsTranscription Elongation, GeneticTranscription, Geneticresearch article31123061open access10.1101/gad.324517.1191549-5477PMC6672053http://genesdev.cshlp.org/content/33/15-16/1008.full.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672053/pdf