Sanchez-Morillo, DanielMuñoz-Zara, PilarLara-Doña, AlejandroLeon-Jimenez, Antonio2022-10-202022-10-202020-02-20Sanchez-Morillo D, Muñoz-Zara P, Lara-Doña A, Leon-Jimenez A. Automated Home Oxygen Delivery for Patients with COPD and Respiratory Failure: A New Approach. Sensors. 2020 Feb 20;20(4):1178http://hdl.handle.net/10668/4266Long-term oxygen therapy (LTOT) has become standard care for the treatment of patients with chronic obstructive pulmonary disease (COPD) and other severe hypoxemic lung diseases. The use of new portable O2 concentrators (POC) in LTOT is being expanded. However, the issue of oxygen titration is not always properly addressed, since POCs rely on proper use by patients. The robustness of algorithms and the limited reliability of current oximetry sensors are hindering the effectiveness of new approaches to closed-loop POCs based on the feedback of blood oxygen saturation. In this study, a novel intelligent portable oxygen concentrator (iPOC) is described. The presented iPOC is capable of adjusting the O2 flow automatically by real-time classifying the intensity of a patient's physical activity (PA). It was designed with a group of patients with COPD and stable chronic respiratory failure. The technical pilot test showed a weighted accuracy of 91.1% in updating the O2 flow automatically according to medical prescriptions, and a general improvement in oxygenation compared to conventional POCs. In addition, the usability achieved was high, which indicated a significant degree of user satisfaction. This iPOC may have important benefits, including improved oxygenation, increased compliance with therapy recommendations, and the promotion of PA.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/COPDOxygen concentratorOxygen therapyAutomatic oxygen concentratorPhysical activityMachine learningRespiratory medicinePortable oxygen concentratorOxygen deliveryPulmonary disease, chronic obstructiveEjercicio físicoAprendizaje automáticoNeumologíaEnfermedad pulmonar obstructiva crónicaMedical Subject Headings::Information Science::Information Science::Computing Methodologies::AlgorithmsMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Chalcogens::OxygenMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Respiratory Therapy::Oxygen Inhalation TherapyMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic ObstructiveMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of ResultsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysis::Blood Gas Analysis::OximetryMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Human Activities::ExerciseMedical Subject Headings::Phenomena and Processes::Mathematical Concepts::AlgorithmsMedical Subject Headings::Diseases::Respiratory Tract Diseases::Respiration Disorders::Respiratory InsufficiencyMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseasesresearch article32093418open access10.3390/s200411781424-8220PMC7070269