Casares-Marfil, DesiréKerick, MartinAndrés-León, EduardoBosch-Nicolau, PauMolina, IsraelChagas Genetics CYTED NetworkMartin, JavierAcosta-Herrera, Marialbert2025-01-072025-01-072021-10-29https://hdl.handle.net/10668/24675A recent genome-wide association study (GWAS) identified a locus in chromosome 11 associated with the chronic cardiac form of Chagas disease. Here we aimed to elucidate the potential functional mechanism underlying this genetic association by analyzing the correlation among single nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) levels as cis methylation quantitative trait loci (cis-mQTL) within this region. A total of 2,611 SNPs were tested against 2,647 DNAm sites, in a subset of 37 chronic Chagas cardiomyopathy patients and 20 asymptomatic individuals from the GWAS. We identified 6,958 significant cis-mQTLs (False Discovery Rate [FDR]enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultAgedCarrier ProteinsChagas CardiomyopathyDNA MethylationDNA Polymerase IFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPhospholipases A2, Calcium-IndependentPolymorphism, Single NucleotideQuantitative Trait LociRepressor ProteinsTumor Suppressor Proteinsresearch article34714828open access10.1371/journal.pntd.00098741935-2735PMC8580254https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009874&type=printablehttps://pmc.ncbi.nlm.nih.gov/articles/PMC8580254/pdf