Melguizo-Rodríguez, LucíaCostela-Ruiz, Victor J.Manzano-Moreno, Francisco JavierRuiz, ConcepciónIllescas-Montes, Rebeca2022-06-032022-06-032020-07-21Melguizo-Rodríguez L, Costela-Ruiz VJ, Manzano-Moreno FJ, Ruiz C, Illescas-Montes R. Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies. Int J Mol Sci. 2020 Jul 21;21(14):5173http://hdl.handle.net/10668/3673Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner-and the results of its analysis complement clinical and histopathological findings in the diagnosis of multiple diseases. The objective of this review was to offer an update on the contribution of salivary biomarkers to the diagnosis and prognosis of diseases of the oral cavity, including oral lichen planus, periodontitis, Sjögren's syndrome, oral leukoplakia, peri-implantitis, and medication-related osteonecrosis of the jaw. Salivary biomarkers such as interleukins, growth factors, enzymes, and other biomolecules have proven useful in the diagnosis and follow-up of these diseases, facilitating the early evaluation of malignization risk and the monitoring of disease progression and response to treatment. However, further studies are required to identify new biomarkers and verify their reported role in the diagnosis and/or prognosis of oral diseases.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Salivary biomarkerCytokinesOral pathologyDiagnosisSalivaBiomarcadoresCitocinasPatología bucalDiagnósticoMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological MarkersMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and ProteinsMedical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::InterleukinsMedical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Mouth Neoplasms::Leukoplakia, OralMedical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Lichen Planus, OralMedical Subject Headings::Anatomy::Body Regions::Head::Face::MouthMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Necrosis::OsteonecrosisMedical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Peri-ImplantitisMedical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::PeriodontitisMedical Subject Headings::Anatomy::Fluids and Secretions::Bodily Secretions::SalivaMedical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Salivary Gland Diseases::Xerostomia::Sjogren's Syndromereview article32708341Acceso abierto10.3390/ijms211451731422-0067PMC7403990