Alba-Linero, CarmenRodriguez Calvo de Mora, MarinaLavado Valenzuela, RocíoPascual Cascón, María JesúsMartín Cerezo, Alejandra RosarioÁlvarez Pérez, MartinaRecio, Luis ViciosoJerez Aragonés, José ManuelGarcía Campos, José Manuel2023-02-092023-02-092020http://hdl.handle.net/10668/15997To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P= 0, OS P= 0.0003), Oxford test OU (OD P= 0.01, OS P= 0.0049), and CD8+ lymphocytes OU (OD P= 0.003, OS P= 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.enAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Allogeneic stem cell transplantationOSDI testSchirmer's testconjunctival CD8+ lymphocyte detectiongraft-versus-host diseaseConjunctivaGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansProspective StudiesReferral and Consultationresearch article32709775open access10.4103/ijo.IJO_1865_191998-3689PMC7640859https://doi.org/10.4103/ijo.ijo_1865_19https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640859/pdf