Christakoudi, SofiaTsilidis, Konstantinos KMuller, David CFreisling, HeinzWeiderpass, ElisabeteOvervad, KimSöderberg, StefanHäggström, ChristelPischon, TobiasDahm, Christina CZhang, JieTjønneland, AnneHalkjær, JytteMacDonald, ConorBoutron-Ruault, Marie-ChristineMancini, Francesca RomanaKühn, TilmanKaaks, RudolfSchulze, Matthias BTrichopoulou, AntoniaKarakatsani, AnnaPeppa, EleniMasala, GiovannaPala, ValeriaPanico, SalvatoreTumino, RosarioSacerdote, CarlottaQuiros, J RamonAgudo, AntonioSanchez-Perez, Maria-JoseCirera, LluisBarricarte-Gurrea, AurelioAmiano, PilarMemarian, EnsiehSonestedt, EmilyBueno-de-Mesquita, BasMay, Anne MKhaw, Kay-TeeWareham, Nicholas JTong, Tammy Y NHuybrechts, IngeNoh, HwayoungAglago, Elom KEllingjord-Dale, MereteWard, Heather AAune, DagfinnRiboli, Elio2023-02-092023-02-092020-08-06Christakoudi S, Tsilidis KK, Muller DC, Freisling H, Weiderpass E, Overvad K, et al. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort. Sci Rep. 2020 Sep 3;10(1):14541http://hdl.handle.net/10668/16203Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Body Mass IndexCohort StudiesEuropeFemaleHumansMaleObesity, AbdominalProportional Hazards ModelsRisk FactorsWaist CircumferenceWaist-Hip Ratioresearch article32883969open accessCircunferencia de la cinturaFactores de riesgoModelos de riesgos proporcionalesObesidad abdominalRelación cintura-cadera10.1038/s41598-020-71302-52045-2322PMC7471961https://www.nature.com/articles/s41598-020-71302-5.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471961/pdf