D'Antonio, FrancescoSen, CihatMascio, Daniele DiGalindo, AlbertoVillalain, CeciliaHerraiz, IgnacioArisoy, ResulOvayolu, AliEroglu, HasanGuerra-Canales, ManuelLadella, SubhashiniCojocaru, LiviuTuran, OzhanTuran, SifaHadar, EranBrzezinski-Sinai, Noa ADollinger, SarahUyaniklar, OzlemOcakouglu, Sakine RahimliAtak, ZelihaPremru-Srsen, TanjaKornhauser-Cerar, LilijanaDruskovic, MirjamPles, LianaGunduz, ReyhanAgacayak, ElifSchvartzman, Javier AlfonsoMalbran, Mercedes NegriLiberati, MarcoSebastiano, Francesca DiOronzi, LudovicaCerra, ChiaraBuca, DaniloCagnacci, AngeloRamone, AriannaBarra, FabioCarosso, AndreaBenedetto, ChiaraCosma, StefanoPintiaux, AxelleDaelemans, CarolineCosta, ElenaOzel, AyşegülMuhçu, MuratJimenez-Lopez, Jesus SAlvarado, ClaraLuengo-Piqueras, AnnaOliva, Dolores EstebanSchera, Giovanni Battista LucaVolpe, NicolaFrusca, TizianaSamardjiski, IgorSimeonova, SlagjanaPapestiev, Irena AleksioskaHojman, JavierTurkcuoglu, IlginCromi, AntonellaLagana, Antonio SimoneGhezzi, FabioSirico, AngeloFamiliari, AlessandraScambia, GiovanniSukhikh, Zulfiya Khodjaeva Gennady TGorina, Ksenia Ade Sa, Renato Augusto MoreiraVaz, MarianaFeuerschuette, Otto Henrique MayGatta, Anna Nunzia DellaYoussef, AlyDonna, Gaetana DiMartinez-Varea, AliciaLoscalzo, GabrielaMorales Rosello, JoseStefanovic, VedranNupponen, IrmeliNelskyla, KaisaAyala, RodrigoMolpeceres, Rebeca GarroteVazquez, Asuncion PinoSandri, FabrizioCataneo, IlariaLenzi, MarinellaHaberal, Esra TustasHuertas, ErasmoSanchez, AmadeoArango, PedroBermejo, AmandaGonzalez-Alcantara, Maria MonicaGoynumer, GokhanOkuyan, ErhanMadalina, CiuhodaruGuisan, Ana ConcheiroMartinez-Schulte, AlejandraEsposito, ValentinaDe-Robertis, ValentinaZdjelar, SnezanaLackovic, MilanMihajlovic, SladjanaJekova, NellySaccone, GabrieleAslan, Mehmet MusaDedda, Maria Carmela DiChalid, MaisuriMoros-Canache, Jose EnriqueDaskalakis, GeorgeAntsaklis, PanosVega, Enrique CriadoCueto, ElisaTaccaliti, ChiaraAykanat, YelizOzlem Genç, ŞerifeFroessler, BerndRadulova, Petya AngelovaMorano, DanilaBianchi, BeatriceMarino, Maria Giulia LombanaMeccariello, GabriellaRohatgi, BinduSchiattarella, AntonioMorlando, MaddalenaColacurci, NicolaVillasco, AndreaBiglia, NicolettaSantos-Marques, Ana LuizaGatti, AlessandraLuvero, DanielaAngioli, RobertoPittaro, AlejandroLila, AlbertZlatohlavkova, Blanka2023-02-092023-02-092021-02-10D'Antonio F, Sen C, Mascio DD, Galindo A, Villalain C, Herraiz I, et al. Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019. Am J Obstet Gynecol MFM. 2021 Jul;3(4):100329http://hdl.handle.net/10668/17224It has still to be ascertained whether severe acute respiratory syndrome coronavirus 2 infection in pregnancy is associated with worse maternal and fetal outcomes compared to low risk gestations. This study aimed to evaluate maternal and perinatal outcomes in high- and low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection. This was a multinational retrospective cohort study involving women with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection from 76 centers from 25 countries in Europe, the United States, South America, Asia, and Australia from April 4, 2020, to October 28, 2020. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit, use of mechanical ventilation, or death. The secondary outcome was a composite measure of adverse perinatal outcome, including miscarriage, fetal loss, neonatal and perinatal death, and admission to the neonatal intensive care unit. All outcomes were assessed in high- and low-risk pregnancies. Pregnancies were considered high risk in case of either preexisting chronic medical conditions in pregnancy or obstetrical disorders occurring in pregnancy. The Fisher exact test and logistic regression analysis were used to analyze the data. A total of 887 singleton pregnancies who tested positive for severe acute respiratory syndrome coronavirus 2 infection using reverse transcription-polymerase chain reaction of nasal and pharyngeal swab specimens were included in the study. The risk of composite adverse maternal outcomes was higher in high-risk pregnancies than in low-risk pregnancies (odds ratio, 1.52; 95% confidence interval, 1.03-2.24; P=.035). In addition, women carrying high-risk pregnancies were at higher risk of hospital admission (odds ratio, 1.48; 95% confidence interval, 1.07-2.04; P=.002), presence of severe respiratory symptoms (odds ratio, 2.13; 95% confidence interval, 0.41-3.21; P=.001), admission to the intensive care unit (odds ratio, 2.63; 95% confidence interval, 1.42-4.88), and invasive mechanical ventilation (odds ratio, 2.65; 95% confidence interval, 1.19-5.94; P=.002). When exploring perinatal outcomes, high-risk pregnancies were at high risk of adverse perinatal outcomes (odds ratio, 1.78; 95% confidence interval, 0.15-2.72; P=.009). However, such association was mainly because of the higher incidence of miscarriage in high-risk pregnancies compared with that in low-risk pregnancies (5.3% vs 1.6%, P=.008); furthermore, there was no difference in other explored outcomes between the 2 study groups. At logistic regression analysis, maternal age (odds ratio, 1.12; 95% confidence interval, 1.02-1.22; P=.023) and high-risk pregnancy (odds ratio, 4.21; 95% confidence interval, 3.90-5.11; P High-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection were at higher risk of adverse maternal outcomes than low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/CoronavirusCoronavirus disease 2019InfectionPregnancySevere acute respiratory syndrome coronavirus 2AsiaAustraliaCOVID-19EuropeFemaleHumansInfant, NewbornIntensive Care Units, NeonatalPregnancyPregnancy Complications, InfectiousPregnancy OutcomeRetrospective StudiesSARS-CoV-2South Americaresearch article33621713open accessEmbarazoOportunidad relativaIntervalos de confianzaEmbarazo de alto riesgoRespiración artificialAborto espontáneo10.1016/j.ajogmf.2021.1003292589-9333PMC7896113http://www.ajogmfm.org/article/S2589933321000240/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896113/pdf