Morales-Garcia, Jose AGine, ElenaHernandez-Encinas, ElenaAguilar-Morante, DianaSierra-Magro, AnaSanz-SanCristobal, MarinaAlonso-Gil, SandraSanchez-Lanzas, RaulCastaño, Jose GSantos, AngelPerez-Castillo, Ana2023-01-252023-01-252017-10-19Morales-Garcia JA, Gine E, Hernandez-Encinas E, Aguilar-Morante D, Sierra-Magro A, Sanz-SanCristobal M, et al. CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease. Sci Rep. 2017 Oct 19;7(1):13526.http://hdl.handle.net/10668/11703The CCAAT/Enhancer binding protein β (C/EBPβ) is a transcription factor involved in numerous physiological as well as pathological conditions in the brain. However, little is known regarding its possible role in neurodegenerative disorders. We have previously shown that C/EBPβ regulates the expression of genes involved in inflammatory processes and brain injury. Here, we have analyzed the effects of C/EBPβ interference in dopaminergic cell death and glial activation in the 6-hydroxydopamine model of Parkinson's disease. Our results showed that lentivirus-mediated C/EBPβ deprivation conferred marked in vitro and in vivo neuroprotection of dopaminergic cells concomitant with a significant attenuation of the level of the inflammatory response and glial activation. Additionally, C/EBPβ interference diminished the induction of α-synuclein in the substantia nigra pars compacta of animals injected with 6-hydroxydopamine. Taking together, these results reveal an essential function for C/EBPβ in the pathways leading to inflammatory-mediated brain damage and suggest novel roles for C/EBPβ in neurodegenerative diseases, specifically in Parkinson's disease, opening the door for new therapeutic interventions.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/NeurologyParkinson's diseaseAnimalsApoptosisCCAAT-Enhancer-Binding Protein-betaCells, CulturedDisease Models, AnimalDopaminergic NeuronsHumansMaleMesencephalonOxidopamineParkinson DiseasePars CompactaRNA InterferenceRNA, Small InterferingRatsRats, Wistaralpha-Synucleinresearch article29051532open accessEnfermedades neurodegenerativasEnfermedad de ParkinsonOxidopaminaEncéfaloNeuroprotecciónTécnicas In VitroLentivirusSinucleínas10.1038/s41598-017-13269-42045-2322PMC5648790https://www.nature.com/articles/s41598-017-13269-4.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648790/pdf