Ramos-Rincon, Jose-ManuelBuonaiuto, VeronicaRicci, MicheleMartin-Carmona, JesicaParedes-Ruiz, DianaCalderon-Moreno, MariaRubio-Rivas, ManelBeato-Perez, Jose-LuisArnalich-Fernández, FranciscoMonge-Monge, DanielVargas-Nuñez, Juan-AntonioAcebes-Repiso, GonzaloMendez-Bailon, ManuelPerales-Fraile, IsabelGarcia-Garcia, Gema-MariaGuisado-Vasco, PabloAbdelhady-Kishta, AlaaeldeenPascual-Perez, Maria-de-Los-ReyesRodriguez-Fernandez-Viagas, CristinaMontaño-Martinez, AdrianLopez-Ruiz, AntonioGonzalez-Juarez, Maria-JesusPerez-Garcia, CristinaCasas-Rojo, Jose-ManuelGomez-Huelgas, Ricardo2023-02-092023-02-092020-10-26Ramos-Rincon JM, Buonaiuto V, Ricci M, Martín-Carmona J, Paredes-Ruíz D, Calderón-Moreno M, et al. Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized With COVID-19 in Spain. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):e28-e37http://hdl.handle.net/10668/16477Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with COVID-19. This study aims to describe the clinical characteristics of very old inpatients with COVID-19 and identify risk factors for in-hospital mortality at admission. We conducted a nationwide, multicenter, retrospective, observational study in patients ≥ 80 years hospitalized with COVID-19 in 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1-May 29, 2020). The primary outcome was in-hospital mortality. A uni- and multivariate logistic regression was performed to assess predictors of mortality at admission. A total of 2772 consecutive patients (49.4% men, median age 86.3 years) were analyzed. Rates of atherosclerotic cardiovascular disease, diabetes mellitus, dementia, and Barthel Index This first large, multicenter cohort of very old inpatients with COVID-19 shows that age, male sex, and poor preadmission functional status-not comorbidities-are independently associated with in-hospital mortality. Severe COVID-19 at admission is related to poor prognosis.enAge ≥ 80COVID-19MortalityPrognostic factorsSARS-CoV-2Área de Gestión Sanitaria Este de Málaga-AxarquíaAged, 80 and overCOVID-19FemaleHospital MortalityHospitalizationHumansMalePneumonia, ViralPrognosisRetrospective StudiesRisk FactorsSARS-CoV-2Spainresearch article33103720Restricted AccessMortalidad HospitalariaPacientes InternosFactores de RiesgoSistema de RegistrosDemenciaEnfermedades Cardiovasculares10.1093/gerona/glaa2431758-535XPMC7797762https://europepmc.org/articles/pmc7797762?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797762/pdf