García-Padilla, CarlosLozano-Velasco, EstefaníaLópez-Sánchez, CarmenGarcia-Martínez, VirginioAranega, AmeliaFranco, Diego2025-01-072025-01-072021-02-17https://hdl.handle.net/10668/24605: All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/developmentdiseaselncRNAsmicroRNAsretinoic acidresearch article33671241open access10.3390/ncrna70100132311-553XPMC8005990https://www.mdpi.com/2311-553X/7/1/13/pdf?version=1615191642https://pmc.ncbi.nlm.nih.gov/articles/PMC8005990/pdf