Santos-García, Diegode Deus, TeresaCores, CarlosCanfield, HectorPaz González, Jose MMartínez Miró, CristinaValdés Aymerich, LorenaSuárez, EsterJesús, SilviaAguilar, MiquelPastor, PauPlanellas, LluisCosgaya, MarinaGarcía Caldentey, JuanCaballol, NuriaLegarda, InesHernández-Vara, JorgeCabo, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, Maria ACatalán, Maria JNogueira, VictorPuente, VictorDotor, JulioBorrué, CarmenSolano, BertaÁlvarez Sauco, MariaVela, LydiaEscalante, SoniaCubo, EstherCarrillo, FranciscoMartínez Castrillo, Juan CSánchez Alonso, PilarAlonso, GemmaLópez Ariztegui, NuriaGastón, ItziarKulisevsky, JaimeBlázquez, MartaSeijo, ManuelRúiz Martínez, JavierValero, CaridadKurtis, Monicade Fábregues, OriolArdura, JessicaAlonso, RubenOrdás, CarlosLópez Díaz, Luis MMcAfee, DarrianMartinez-Martin, PabloMir, PabloCoppadis Study Group,2025-01-072025-01-072021-06-302075-4426https://hdl.handle.net/10668/27682Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Parkinson’s diseasemoodnon-motor symptomsprogressionquality of liferesearch article34209166open access10.3390/jpm11070626PMC8305732https://www.mdpi.com/2075-4426/11/7/626/pdf?version=1625108994https://pmc.ncbi.nlm.nih.gov/articles/PMC8305732/pdf