Paslakis, GeorgiosAgüera, ZaidaGranero, RoserSánchez, IsabelRiesco, NadineJiménez-Murcia, SusanaFernández-García, Jose CGarrido-Sánchez, LourdesTinahones, Francisco JCasanueva, Felipe FBaños, Rosa MBotella, CristinaCrujeiras, Ana BTorre, Rafael de laFernández-Real, Jose MFrühbeck, GemaOrtega, Francisco JRodríguez, AmaiaSerra-Majem, LuísFitó, MontserratMenchón, José MFernández-Aranda, Fernando2023-01-252023-01-252019-05-20http://hdl.handle.net/10668/14006Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.enAnorexia nervosaAppetite regulationDecision-makingGhrelinNeuropsychological performanceAdultAnorexia NervosaAppetiteCase-Control StudiesCohort StudiesDecision MakingGhrelinHumansModels, BiologicalNeuropsychological TestsYoung Adultresearch article31121263open access10.1016/j.mce.2019.04.0211872-8057http://repositori.upf.edu/bitstream/10230/43763/1/pastakis-mce-asso.pdf