Nieto-Ruiz, AnaDiéguez, EstefaníaSepúlveda-Valbuena, NataliaHerrmann, FlorianCerdó, TomásLópez-Torrecillas, FranciscaDe-Castellar, RoserJiménez, JesúsPérez-García, MiguelMiranda, María T.Catena, AndrésGarcía-Santos, José A.Bermúdez, Mercedes G.Campoy, Cristina2022-09-212022-09-212020-12-15Nieto-Ruiz A, Diéguez E, Sepúlveda-Valbuena N, Herrmann F, Cerdó T, López-Torrecillas F, et al. The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study. Nutrients. 2020 Dec 15;12(12):3825http://hdl.handle.net/10668/4082Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children's behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Different statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological affective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial effects on internalizing and total problem rate in their offspring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development.enAtribución 4.0 InternacionalAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Infant formulaMilk fat globule membraneLong-chain polyunsaturated fatty acidsBioactive compoundsChildren behaviorBreastfeedingBrain developmentNeurodevelopmental disordersFórmulas infantilesLactancia maternaTrastornos del neurodesarrolloÁcidos grasos insaturadosConducta infantilMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena::Breast FeedingMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Child BehaviorMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Human Development::Child DevelopmentMedical Subject Headings::Persons::Persons::Age Groups::Child::Child, PreschoolMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Double-Blind MethodMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, UnsaturatedMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Foods, Specialized::Food, FortifiedMedical Subject Headings::Chemicals and Drugs::Lipids::GlycolipidsMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycoconjugates::GlycoproteinsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Persons::Persons::Age Groups::InfantMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Beverages::Milk::Infant FormulaMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological PhenomenaMedical Subject Headings::Persons::Persons::Age Groups::Infant::Infant, NewbornMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Psychiatry and Psychology::Mental DisordersMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective StudiesMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::Synbioticsresearch article33333767Acceso abierto10.3390/nu121238252072-6643PMC7765166