Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry.

Garcia-Cervera, CarlesGiner-Galvañ, VicenteWikman-Jorgensen, PhilipLaureiro, JaimeRubio-Rivas, ManuelGurjian-Arena, AnthonyArnalich-Fernandez, FranciscoBeato-Perez, Jose LuisVargas-Nuñez, Juan AntonioGonzalez-Igual, Jesus JavierDiez-Manglano, JesusMendez-Bailon, ManuelGarcia-Blanco, Maria JoseFreire-Castro, Santiago JAranda-Lobo, JuditManzano, LuisMagallanes-Gamboa, Jeffrey OskarArribas-Perez, LuisGonzalez-Moraleja, JulioCalderon-Hernaiz, RuthGarcia-Alegria, JavierGonzalez-Noya, AmaraGomez-Huelgas, RicardoLumbreras-Bermejo, CarlosAnton-Santos, Juan Miguel2023-02-092023-02-092021-07-21García-Cervera C, Giner-Galvañ V, Wikman-Jorgensen P, Laureiro J, Rubio-Rivas M, Gurjian Arena A, et al. Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry. J Gen Intern Med. 2021 Nov;36(11):3478-3486http://hdl.handle.net/10668/18231Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation 1.0 μg/ml treated with prophylactic dose (p 2.0 μg/ml treated with intermediate dose (p = 0.0001), and 31.3% for those with pDd >3.0 μg/ml and full anticoagulation (p = 0.0183). In hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation.enCOVID-19D-dimerSARS-CoV-2Deep vein thrombosisPulmonary embolismVenous thrombotic eventCOVID-19Fibrin Fibrinogen Degradation ProductsHospitalizationHumansRegistriesRetrospective StudiesSARS-CoV-2Venous ThromboembolismVenous ThrombosisEstimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry.research article34287774Restricted AccessDosificaciónTrombosis de la VenaDisneaEmbolia PulmonarTaquipnea10.1007/s11606-021-07017-81525-1497PMC8294343https://link.springer.com/content/pdf/10.1007/s11606-021-07017-8.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294343/pdf