De Luca, GiuseppeAlgowhary, MagdyUguz, BeratOliveira, Dinaldo CGanyukov, VladimirZimbakov, ZanCercek, MihaJensen, Lisette OkkelsLoh, Poay HuanCalmac, LucianFerrer, Gerard Roura IQuadros, AlexandreMilewski, MarekScotto D'Uccio, Fortunatovon Birgelen, ClemensVersaci, FrancescoTen Berg, JurrienCasella, GianniWong Sung Lung, AaronKala, PetrDíez Gil, José LuisCarrillo, XavierDirksen, MauritsBecerra-Munoz, Victor MLee, Michael Kang-YinJuzar, Dafsah ArifaJoaquim, Rodrigo de MouraPaladino, RobertoMilicic, DavorDavlouros, PeriklisBakraceski, NikolaZilio, FilippoDonazzan, LucaKraaijeveld, AdriaanGalasso, GennaroArpad, LuxLucia, MarinucciVincenzo, GuiducciMenichelli, MaurizioScoccia, AlessandraYamac, Aylin HaticeUgur Mert, KadirFlores Rios, XacobeKovarnik, TomasKidawa, MichalMoreu, JosèVincent, FlavienFabris, EnricoMartínez-Luengas, Iñigo LozanoBoccalatte, MarcoBosa Ojeda, FranciscoArellano-Serrano, CarlosCaiazzo, GianlucaCirrincione, GiuseppeKao, Hsien-LiSanchis Forés, JuanVignali, LuigiPereira, HelderManzo, StephaneOrdoñez, SantiagoÖzkan, Alev AratScheller, BrunoLehtola, HeidiTeles, RuiMantis, ChristosAntti, YlitaloSilveira, João António BrumZoni, RodrigoBessonov, IvanSavonitto, StefanoKochiadakis, GeorgeAlexopulos, DimitriosUribe, Carlos EKanakakis, JohnFaurie, BenjaminGabrielli, GabrieleBarrios, Alejandro GutierrezBachini, Juan PabloRocha, AlexTam, Frankie Chor-CheungRodriguez, AlfredoLukito, Antonia AnnaSaint-Joy, VeauthyelauPessah, GustavoTuccillo, AndreaCortese, GiulianaParodi, GuidoBouraghda, Mohamed AbedKedhi, ElvinLamelas, PabloSuryapranata, HarryNardin, MatteoVerdoia, Monica2023-05-032023-05-032022-11-132077-0383http://hdl.handle.net/10668/21364The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS−STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19myocardial infarctionpercutaneous coronary interventionsmoking paradoxresearch article36431198open access10.3390/jcm11226722PMC9698021https://www.mdpi.com/2077-0383/11/22/6722/pdf?version=1669166080https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698021/pdf