Salas-Salvado, JordiDiaz-Lopez, AndresRuiz-Canela, MiguelBasora, JosepFito, MontseCorella, DoloresSerra-Majem, LuisWärnberg, JuliaRomaguera, DoraEstruch, RamonVidal, JosepMartinez, J AlfredoAros, FernandoVazquez, ClotildeRos, EmilioVioque, JesusLopez-Miranda, JoseBueno-Cavanillas, AuroraTur, Josep ATinahones, Francisco JMartin, VicenteLapetra, JosePinto, XavierDaimiel, LidiaDelgado-Rodriguez, MiguelMatia, PilarGomez-Gracia, EnriqueDiez-Espino, JavierBabio, NancyCastañer, OlgaSorli, Jose VFiol, MiquelZulet, Maria AngelesBullo, MonicaGoday, AlbertMartinez-Gonzalez, Miguel A2023-01-252023-01-252018-09-29Salas-Salvadó J, Díaz-López A, Ruiz-Canela M, Basora J, Fitó M, Corella D, et al. Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial. Diabetes Care. 2019 May;42(5):777-78http://hdl.handle.net/10668/13151The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention. Overweight/obese adults with metabolic syndrome aged 55-75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively. Diet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P PREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes.enBehavior therapyBlood glucoseCaloric restrictionCardiovascular diseasesAgedDiet, mediterraneanExerciseExercise therapyFemaleFollow-up studiesHumansLife styleMaleMetabolic syndromeMiddle agedObesityOverweightPrediabetic stateRisk factorsWeight lossresearch article30389673open accessDieta mediterráneaEjercicio físicoEstado prediabéticoEstilo de vidaFactores de riesgoObesidadPérdida de pesoSíndrome metabólicoTerapia por ejercicio10.2337/dc18-08361935-5548https://care.diabetesjournals.org/content/diacare/42/5/777.full.pdf