Miranda-Vizuete, AntonioVeal, Elizabeth A2023-01-252023-01-252016-12-27Miranda-Vizuete A, Veal EA. Caenorhabditis elegans as a model for understanding ROS function in physiology and disease. Redox Biol. 2017 Apr;11:708-714.http://hdl.handle.net/10668/10863ROS (reactive oxygen species) are potentially damaging by-products of aerobic metabolism which, unchecked, can have detrimental effects on cell function. However, it is now widely accepted that, at physiological levels, certain ROS play important roles in cell signaling, acting as second messengers to regulate cell choices that contribute to the development, adaptation and survival of plants and animals. Despite important recent advances in the biochemical tools available to study redox-signaling, the molecular mechanisms underlying most of these responses remain poorly understood, particularly in multicellular organisms. As we will review here, C. elegans has emerged as a powerful animal model to elucidate these and other aspects of redox biology.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/AgingCaenorhabditis elegansCuticleInnate immunityPathogen infectionROS detectionReactive oxygen speciesRedox homeostasisWound healingAgingAnimalsCaenorhabditis elegansLongevityModels, AnimalReactive Oxygen Speciesresearch article28193593open accessOxidación-reducciónCélulasVoliciónBiologíaSobrevidaMetabolismoTransducción de señal10.1016/j.redox.2016.12.0202213-2317PMC5304259https://doi.org/10.1016/j.redox.2016.12.020https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304259/pdf