Santos Garcia, DiegoAlvarez Sauco, MariaCalopa, MatildeCarrillo, FatimaEscamilla Sevilla, FranciscoFreire, EricGarcia Ramos, RocioKulisevsky, JaimeGomez Esteban, Juan CarlosLegarda, InesLuquin, Maria Rosario IsabelCastrillo, Juan Carlos MartinezMartinez-Martin, PabloMartinez-Torres, IreneMir, PabloIgnacio, Angel Sesar2023-05-032023-05-032021-12-23Santos García D, Álvarez Sauco M, Calopa M, Carrillo F, Escamilla Sevilla F, Freire E, et al. MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice. Diagnostics (Basel). 2021 Dec 28;12(1):55.2075-4418http://hdl.handle.net/10668/20955Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions: A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Parkinson’s diseasecognitiondependencymotor symptomsnon-motor symptomsHumansTremorActivities of Daily LivingNeoplasm StagingParkinson DiseaseSpainPrognosisAutonomic Nervous System DiseasesPainSleepFatigueSensation DisordersCognitionNational Institutes of Health (U.S.)DementiaStrokeresearch article35054222open accessAccidente cerebrovascularCogniciónDemenciaActividades cotidianasEnfermedad de ParkinsonEnfermedades del sistema nervioso autónomoFatigaSueñoTemblorTrastornos de la sensación10.3390/diagnostics12010055PMC8774369https://www.mdpi.com/2075-4418/12/1/55/pdf?version=1640682903https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774369/pdf