Cruz Melguizo, Sarade la Cruz Conty, María LuisaCarmona Payán, PaolaAbascal-Saiz, AlejandraPintando Recarte, PilarGonzález Rodríguez, LauraCuenca Marín, CeliaMartínez Varea, AliciaOreja Cuesta, Ana BelénRodríguez, Pilar PratsFernández Buhigas, IreneRodríguez Gallego, María VictoriaFernández Alonso, Ana MaríaLópez Pérez, RocíoBroullón Molanes, José RománEncinas Pardilla, María BegoñaRamírez Gómez, MercedesGimeno Gimeno, María JoaquinaSánchez Muñoz, AntonioMartínez-Pérez, OscarOn Behalf Of The Spanish Obstetric Emergency Group S O E G,2023-02-092023-02-092021-05-07http://hdl.handle.net/10668/17897Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2coronavirusdeliverymaternal complicationsperinatal outcomespregnancypremature birthAdultCOVID-19Cohort StudiesFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPregnancyPregnancy ComplicationsPregnancy Complications, InfectiousPregnancy OutcomeProspective StudiesSARS-CoV-2Spainresearch article34067086open access10.3390/v130508531999-4915PMC8151603https://www.mdpi.com/1999-4915/13/5/853/pdf?version=1620446326https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151603/pdf