Cruz-Melguizo, Sarade-la-Cruz-Conty, Maria LuisaCarmona-Payan, PaolaAbascal-Saiz, AlejandraPintando-Recarte, PilarGonzalez-Rodriguez, LauraCuenca-Marin, CeliaMartinez-Varea, AliciaOreja-Cuesta, Ana BelenPrats-Rodriguez, PilarFernandez-Buhigas, IreneRodriguez-Gallego, Maria VictoriaFernandez-Alonso, Ana MariaLopez-Perez, RocioBroullon-Molanes, Jose RomanEncinas-Pardilla, Maria BegoñaRamirez-Gomez, MercedesGimeno-Gimeno, Maria JoaquinaSanchez-Muñoz, AntonioMartinez-Perez, Oscar2023-02-092023-02-092021-05-07Cruz Melguizo S, de la Cruz Conty ML, Carmona Payán P, Abascal-Saiz A, Pintando Recarte P, González Rodríguez L, et al. Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study. Viruses. 2021 May 7;13(5):853http://hdl.handle.net/10668/17897Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p< 0.001); venous thrombotic events (1.5% vs. 0.2%, p <0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms).enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2CoronavirusDeliveryMaternal complicationsPerinatal outcomesPregnancyPremature birthAdultCOVID-19Cohort StudiesFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPregnancyPregnancy ComplicationsPregnancy Complications, InfectiousPregnancy OutcomeProspective StudiesSARS-CoV-2Spainresearch article34067086open accessEmbarazoPreeclampsiaPersonas embarazadasNacimiento prematuroUrgencias médicas10.3390/v130508531999-4915PMC8151603https://www.mdpi.com/1999-4915/13/5/853/pdf?version=1620446326https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151603/pdf