Quintana, Francisco J.Pérez-Sánchez, SoledadFarez, Mauricio F.2016-05-242016-05-242014Quintana FJ, Pérez-Sánchez S, Farez MF. Inmunopatología de la esclerosis múltiple. Medicina (B Aires). 2014; 74(5):404-100025-7680http://hdl.handle.net/10668/2200English Abstract; Journal Article; Review;La esclerosis múltiple es una enfermedad inflamatoria desmielinizante que afecta el sistema nervioso central y que es considerada una de las principales causas de discapacidad en jóvenes adultos. Las causas de la esclerosis múltiple son aún desconocidas, aunque se cree que una combinación de factores genéticos y ambientales resulta en una respuesta autoinmune que promueve la degeneración neuronal/axonal. En esta revisión se analiza la asociación entre la respuesta inmune y la neurodegeneración en la esclerosis múltiple.Multiple sclerosis is an inflammatory demyelinating disease affecting the central nervous system and considered one of the leading causes of disability in young adults. The precise cause of multiple sclerosis is unknown, although the current evidence points towards a combination of genetic and environmental factors leading to an autoimmune response that promotes neuronal degeneration. In this review, we will describe the association between the immune response and neurodegeneration in multiple sclerosis.spaMultiple sclerosisPathogenesisEsclerosis múltiplePatogénesisEnfermedades neurodegenerativasInmunidad celularVaina de mielinaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, CellularMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationMedical Subject Headings::Anatomy::Cells::Connective Tissue Cells::MacrophagesMedical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple SclerosisMedical Subject Headings::Anatomy::Nervous System::Neuroglia::Oligodendroglia::Myelin SheathMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Nerve DegenerationMedical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative DiseasesMedical Subject Headings::Anatomy::Nervous System::NeurogliaMedical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Cytokine-Induced Killer Cells::T-Lymphocytes, CytotoxicMedical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Antibody-Producing Cells::B-Lymphocytesresearch article25347906open access1669-9106