Rodriguez-Gonzalez, MoisesCastellano-Martinez, AnaEstalella-Mendoza, AnaRodriguez-Campoy, PatriciaEstepa-Pedregosa, LorenaCalero-Ruiz, Maria MercedesSaez-Benito Godino, AnaFlores-Gonzalez, Jose Carlos2023-05-032023-05-032022-10-22Rodríguez-González M, Castellano-Martínez A, Estalella-Mendoza A, Rodríguez-Campoy P, Estepa-Pedregosa L, Calero-Ruiz MM, et al. Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study. Pediatr Pulmonol. 2023 Feb;58(2):492-499http://hdl.handle.net/10668/22495We aimed to analyze the correlation of urinary with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and its association with severity in acute bronchiolitis. A pilot observational study was conducted between October 1, 2021 and March 31, 2022 including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere i NT-proBNP assay in time-matched urine and blood samples. The Mann-Whitney U test, Spearman's correlations, and simple linear regression were utilized to analyze the association of urine NT-proBNP levels with serum NT-proBNP and with variables indicative of severe bronchiolitis. Seventeen infants (median age 68 [IQR: 36-91] days) with 36 time-matched samples were included. The urine NT-proBNP was positively and strongly correlated with the serum NT-proBNP concentrations (Spearman's ρ = 0.81 & R2  coefficient = 0.751; p  The urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels and resulted elevated in cases of acute bronchiolitis with complicated evolution, suggesting a potential as a noninvasive tool to assess severity in this setting.enTBAcute bronchiolitisBiomarkersInfections: pneumoniaMyocardial strainNatriuretic peptidesPulmonary hypertensionUrinary NT-proBNPViralHumansInfantBiomarkersBronchiolitisNatriuretic peptide, brainPeptide fragmentsPilot projectsresearch article36314349open accessBiomarcadoresBronquiolitisFragmentos de péptidosLactanteProyectos pilotoPéptido natriurético encefálico10.1002/ppul.262151099-0496https://doi.org/10.22541/au.165702067.78363345/v1