Strauss, S. J.Frezza, A. M.Abecassis, N.Bajpai, J.Bauer, S.Biagini, R.Bielack, S.Blay, J. Y.Bolle, S.Bonvalot, S.Boukovinas, IBovee, J. V. M. G.Boye, K.Brennan, B.Brodowicz, T.Buonadonna, A.de-Alava, E.Dei-Tos, A. P.Del-Muro, X. GarciaDufresne, A.Eriksson, M.Fagioli, F.Fedenko, A.Ferraresi, VFerrari, A.Gaspar, N.Gasperoni, S.Gelderblom, H.Gouin, F.Grignani, G.Gronchi, A.Haas, R.Hassan, A. B.Hecker-Nolting, S.Hindi, N.Hohenberger, P.Joensuu, H.Jones, R. L.Jungels, C.Jutte, P.Kager, L.Kasper, B.Kawai, A.Kopeckova, K.Krakorova, D. A.Le-Cesne, A.Le-Grange, F.Legius, E.Leithner, A.Pousa, A. LopezMartin-Broto, J.Merimsky, O.Messiou, C.Miah, A. B.Mir, O.Montemurro, M.Morland, B.Morosi, C.Palmerini, E.Pantaleo, M. A.Piana, R.Piperno-Neumann, S.Reichardt, P.Rutkowski, P.Safwat, A. A.Sangalli, C.Sbaraglia, M.Scheipl, S.Schoffski, P.Sleijfer, S.Strauss, D.Hall, K. SundbyTrama, A.Unk, M.van-de-Sande, M. A. J.van-der-Graaf, W. T. A.van-Houdt, W. J.Frebourg, T.Ladenstein, R.Casali, P. G.Stacchiotti, S.2025-01-072025-01-072021-11-20Strauss SJ, Frezza AM, Abecassis N, Bajpai J, Bauer S, Biagini R, et al. Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2021 Dec;32(12):1520-1536.0923-7534https://hdl.handle.net/10668/27443Primary bone sarcomas (BSs) account for <0.2% of malignant neoplasms across all ages.1 The overall incidence rate ranges between 0.8 and 0.9 cases per 100 000/year, with single BS types having no more than 0.3 incident cases per 100 000/year. Osteosarcoma and Ewing sarcoma (ES) have a relatively high incidence in the second decade of life, whereas conventional chondrosarcomas are more common in older age.2enbone sarcomaclinical practice guidelinediagnosistreatmentfollow-upmanagementLocalized ewing sarcomaGiant-cell tumorMalignant fibrous histiocytomaHigh-grade osteosarcomaHigh-dose ifosfamideOpen-labelPhase-iiNeoadjuvant chemotherapyPrognostic-factorsMuramyl tripeptideSarcoma, EwingIncidenceOsteosarcomaChondrosarcomaresearch articleRestricted AccessIncidenciaHuesosSarcomaSarcoma de EwingOsteosarcomaVidaNeoplasiasCondrosarcoma10.1016/j.annonc.2021.08.19951569-8041http://www.annalsofoncology.org/article/S0923753421042800/pdf721610600011