Nimptsch, KatharinaAleksandrova, KrasimiraFedirko, VeronikaJenab, MazdaGunter, Marc JSiersema, Peter DWu, KanaKatzke, VerenaKaaks, RudolfPanico, SalvatorePalli, DomenicoMay, Anne MSieri, SabinaBueno-de-Mesquita, BasStandahl, KarinaSanchez-Perez, Maria-JosePerez-Cornago, AuroraOlsen, AnjaTjønneland, AnneBonet, Catalina BonetDahm, Christina CChirlaque, María-DoloresFiano, ValentinaTumino, RosarioGurrea, Aurelio BarricarteBoutron-Ruault, Marie-ChristineMenegaux, FlorenceSeveri, Gianlucavan Guelpen, BethanyLee, Young-AePischon, Tobias2023-05-032023-05-032022-06-06Nimptsch K, Aleksandrova K, Fedirko V, Jenab M, Gunter MJ, Siersema PD, et al. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations. BMC Cancer. 2022 Jun 24;22(1):695.http://hdl.handle.net/10668/20281The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively). The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HumansProspective StudiesRisk FactorsC-Reactive ProteinColorectal NeoplasmsGenetic Predisposition to DiseasePolymorphism, Single Nucleotideresearch article35739525open accessNeoplasias colorrectalesPolimorfismo de nucleótido simplePredisposición genética a la enfermedadProteína C-Reactiva10.1186/s12885-022-09778-91471-2407PMC9229883https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-022-09778-9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229883/pdf