Toledano-Osorio, ManuelAguilera, Fatima S.Munoz-Soto, EstherOsorio, EstrellaToledano, ManuelEscames, GermaineMedina-Castillo, Antonio L.Osorio, Maria T.Lopez-Lopez, Modesto T.Vallecillo-Rivas, MartaOsorio, Raquel2023-02-122023-02-122021-11-030109-5641http://hdl.handle.net/10668/18759Objective. To investigate the effect of novel polymeric nanoparticles (NPs) doped with melatonin (ML) on nano-hardness, crystallinity and ultrastructure of the formed hydroxyapatite after endodontic treatment. Methods. Undoped-NPs and ML-doped NPs (ML-NPs) were tested at radicular dentin, after 24 h and 6 m. A control group without NPs was included. Radicular cervical and apical dentin surfaces were studied by nano-hardness measurements, X-ray diffraction and transmission electron microscopy. Mean and standard deviation were analyzed by ANOVA and StudentNewman-Keuls multiple comparisons (penAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/ApatiteDentinHardnessMelatoninPolymeric nanoparticlesRemineralizationTransmission electron microscopyX-ray diffractionOxidative stressCarious dentinOrganic matrixHydroxyapatiteBoneCementsRemineralizationMineralizationInterfaceTextureresearch articleopen access10.1016/j.dental.2021.09.0011879-0097https://doi.org/10.1016/j.dental.2021.09.001717973400009