Valle-Hita, CristinaDiaz-Lopez, AndresBecerra-Tomas, NereaMartinez-Gonzalez, Miguel AGarcia, Veronica RuizCorella, DoloresGoday, AlbertMartinez, J AlfredoAlonso-Gómez, Angel MWärnberg, JuliaVioque, JesusRomaguera, DoraLopez-Miranda, JoseEstruch, RamonTinahones, Francisco JLapetra, JoseSerra-Majem, LuisCano-Ibañez, NaomiTur, Josep ARubin-Garcia, MariaPinto, XavierDelgado-Rodriguez, MiguelMatia-Martin, PilarVidal, JosepFontao, Sebastian MasDaimiel, LidiaRos, EmilioToledo, EstefaniaSorli, Jose VRoca, CAbete, IztiarMoreno-Rodriguez, AnaiCrespo-Oliva, EdelysCandela-Garcia, InmaculadaMorey, MargaGarcia-Rios, AntonioCasas, RosaFernandez-Garcia, Jose CarlosSantos-Lozano, Jose ManuelDiez-Espino, JavierOrtega-Azorin, CarolinaComas, MZulet, M AngelesSorto-Sanchez, CarolinaRuiz-Canela, MiguelFito, MontseSalas-Salvado, JordiBabio, Nancy2023-05-032023-05-032022-02-11Valle-Hita C, Díaz-López A, Becerra-Tomás N, Martínez-González MA, García VR, Corella D, et al. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk. Eur J Nutr. 2022 Sep;61(6):3095-3108http://hdl.handle.net/10668/19908To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/DASH dietDietary patternsGlomerular filtration rateKidney functionMediterranean dietProtein diet scoreAgedCardiovascular diseasesDiet, mediterraneanHeart disease risk factorsHumansHypertensionKidneyMetabolic syndromeObesityOverweightRisk factorsresearch article35366708open accessDieta mediterráneaEnfermedades cardiovascularesFactores de riesgoFactores de riesgo de enfermedad cardiacaHipertensiónObesidadRiñónSobrepesoSíndrome metabólico10.1007/s00394-022-02838-71436-6215PMC9363380https://link.springer.com/content/pdf/10.1007/s00394-022-02838-7.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363380/pdf