Rodriguez-Pacheco, FNovelle, M GVazquez, M JGarcia-Escobar, ESoriguer, FRojo-Martinez, GGarcía-Fuentes, EMalagon, M MDieguez, C2013-12-192013-12-192013Rodriguez-Pacheco F, Novelle MG, Vazquez MJ, Garcia-Escobar E, Soriguer F, Rojo-Martinez G, et al. Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro. Mediators Inflamm.; 2013:4797390962-9351http://hdl.handle.net/10668/1440Journal Article; Research Support, Non-U.S. Gov't;The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.enResistinaAntagonistas de la insulinaInflamaciónInmunidadIngestión de AlimentosGónadasHormona del crecimientoRatasHipófisisLipogénesisMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::ResistinMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Insulin AntagonistsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::ImmunityMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutrition Processes::EatingMedical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::GonadsMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth HormoneMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::RatsMedical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Pituitary GlandMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipogenesisresearch article23710116open access10.1155/2013/4797391466-1861PMC3654331