Yung, Diana ERondonotti, EmanueleGiannakou, AndryAvni, TomerRosa, BrunoToth, ErvinLucendo, Alfredo JSidhu, ReenaBeaumont, HannekeEllul, PierreNegreanu, LucianJiménez-Garcia, Victoria AlejandraMcNamara, DeidreKopylov, UriElli, LucaTriantafyllou, KonstantinosShibli, FahmiRiccioni, Maria ElenaBruno, MauroDray, XavierPlevris, John NKoulaouzidis, AAnd the Capsule Endoscopy in Young Patients with IDA research groupArgüelles-Arias, FedericoBecq, AymericBranchi, FedericaTejero-Bustos, María ÁngelesCotter, JoseEliakim, RamiFerretti, FrancescaGralnek, Ian MHerrerias-Gutierrez, Juan ManuelHussey, MaryJacobs, MaartenJohansson, Gabriele WurmMcAlindon, MarkMontiero, SaraNemeth, ArturPennazio, MarcoRattehalli, DeepaStemate, AnaTortora, AnnalisaTziatzios, Georgios2023-01-252023-01-252017-02-012050-6406http://hdl.handle.net/10668/11831Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. This was a retrospective, multicentre study (2010-2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age 50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression. Data on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 ± 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn's disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3-11.3; p = 0.01; and OR: 0.96; 95%CI: 0.92-0.99; p = 0.03; respectively). Our model also demonstrates association between use of antiplatelets and significant SB pathology, although due to the small number of patients, definitive conclusions cannot be drawn. In IDA patients ≤50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.enCapsule endoscopyiron deficiency anaemianeoplasiasmall bowelyoungresearch article29163963open access10.1177/2050640617692501PMC5676544https://journals.sagepub.com/doi/pdf/10.1177/2050640617692501https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676544/pdf