Martinez-Urbistondo, DiegoSan Cristobal, RodrigoSanVillares, PaulaMartinez-Gonzalez, Miguel AngelBabio, NancyCorella, DoloresDel Val, Jose LuisOrdovas, Jose MAlonso-Gomez, Angel MWärnberg, JuliaVioque, JesusRomaguera, DoraLopez-Miranda, JoseEstruch, RamonTinahones, Francisco JLapetra, JoseSerra-Majem, J LuisBueno-Cavanillas, AuroraTur, Josep AMarcos, AlbaPinto, XavierDelgado-Rodriguez, MiguelMatia-Martin, PilarVidal, JosepVazquez, ClotildeRos, EmilioBullon Vela, Maria VanessaPalau, AntoniMasague, MartaAbete, ItziarMoreno-Rodriguez, AnaiCandela-Garcia, InmaKonieczna, JadwigaGarcia-Rios, AntonioJuarez, Oscar LeceaMartin, PacoGoday, AlbertZulet, M AngelesVaquero-Luna, JessicaOrea, Maria Del Carmen SayonMegias, IsabelBaltasar, EnricMartinez, J AlfredoDaimiel, Lidia2023-05-032023-05-032022-04-26Martínez-Urbistondo D, San Cristóbal R, Villares P, Martínez-González MÁ, Babio N, Corella D, et al. Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort. Front Endocrinol (Lausanne). 2022 Jun 29;13:8687951664-2392http://hdl.handle.net/10668/20564To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoLenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HRQoLNAFLDMediterranean dietMetabolic syndromePhysical activityAgedFemaleHumansLife styleMaleMetabolic syndromeMiddle agedNon-alcoholic fatty liver diseaseProspective studiesQuality of liferesearch article35846291open accessCalidad de vidaEnfermedad del hígado graso no alcohólicoEstilo de vidaEstudios prospectivosSíndrome metabólico10.3389/fendo.2022.868795PMC9276971https://www.frontiersin.org/articles/10.3389/fendo.2022.868795/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276971/pdf