Millón, CarmeloFlores-Burgess, AntonioNarváez, ManuelBorroto-Escuela, Dasiel OGago, BelénSantín, LuisCastilla-Ortega, EstelaNarváez, José ÁngelFuxe, KjellDíaz-Cabiale, Zaida2023-01-252023-01-252017-01-31http://hdl.handle.net/10668/10865Galanin is a 29 amino acid neuropeptide widely distributed in neurons within the central nervous system. Galanin exerts its biological activities through three different G protein-receptors and participates in a number of functions, including mood regulation. Not only Galanin but also Galanin N-terminal fragments like Galanin(1-15) are active at the central level. In this work, we review the latest findings in studies on Galanin and Galanin(1-15) in depression-related behaviours. Our focus is on animal models for depression, and we pay some attention to research data obtained in human studies. Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.enDepressionGalaninAnimalsCentral Nervous SystemDepressionDepressive DisorderGalaninHumansNeuropeptidesReceptors, Galaninresearch article28196617open access10.1016/j.npep.2017.01.0041532-2785https://riuma.uma.es/xmlui/bitstream/10630/22798/1/GAL15-rewiev.pdf