Cornejo-Garcia, J ARomano, AGueant-Rodriguez, R MOussalah, ABlanca-Lopez, NGaeta, FTramoy, DJosse, TDoña, ITorres, M JCanto, GBlanca, MGueant, J-L2023-01-252023-01-252015-04-14Cornejo-García JA, Romano A, Guéant-Rodríguez RM, Oussalah A, Blanca-López N, Gaeta F, et al. A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics J. 2016 Feb;16(1):79-82http://hdl.handle.net/10668/9750Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.enPolymorphism, Single NucleotideProtein Structure, TertiarySpainbeta-LactamsBlood ProteinsAdultAnti-Bacterial AgentsCase-Control StudiesDrug HypersensitivityExonsFemaleGalectin 3GalectinsHumansHypersensitivity, ImmediateImmunoglobulin EItalyMaleMiddle Agedresearch article25869013Restricted accessInmunoglobulina EHipersensibilidadGalectina 3GalactosaLectinas10.1038/tpj.2015.241473-1150