Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.

Sandoval-Alzate, Hector FabioAgudelo-Zapata, YessicaGonzalez-Clavijo, Angelica MariaPoveda, Natalia EEspinel-Pachon, Cristian FelipeEscamilla-Castro, Jorge AugustoMarquez-Julio, Heidy LorenaAlvarado-Quintero, HernandoRojas-Rodriguez, Fabian GuillermoArteaga-Diaz, Juan ManuelEslava-Schmalbach, Javier HernandoGarces-Gutierrez, Maria FernandaVrontakis, MariaCastaño, Justo PLuque, Raul MDieguez, CarlosNogueiras, RubenCaminos, Jorge E2023-01-252023-01-252016-07-18Sandoval-Alzate HF, Agudelo-Zapata Y, González-Clavijo AM, Poveda NE, Espinel-Pachón CF, Escamilla-Castro JA, et al. Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test. Sci Rep. 2016 Aug 23;6:31661http://hdl.handle.net/10668/10385Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m(2)) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m(2)). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p p<0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA–IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120minutes during the OGTT is the most predictive variable for serum GAL levels (p<0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultBlood glucoseBody mass indexCross-sectional studiesGalaninGlucose tolerance testHumansInsulinMaleObesityRegression analysisYoung adultSerum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.research article27550417open accessAnálisis de regresiónGalaninaInsulinaObesidadPrueba de tolerancia a la glucosa10.1038/srep316612045-2322PMC4994037https://www.nature.com/articles/srep31661.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994037/pdf