Carrera, CatyCárcel-Márquez, JaraCullell, NataliaTorres-Águila, NuriaMuiño, ElenaCastillo, JoséSobrino, TomásCampos, FranciscoRodríguez-Castro, EmilioLlucià-Carol, LaiaMillán, MònicaMuñoz-Narbona, LucíaLópez-Cancio, ElenaBustamante, AlejandroRibó, MarcÁlvarez-Sabín, JoséJiménez-Conde, JordiRoquer, JaumeGiralt-Steinhauer, EvaSoriano-Tárraga, CarolinaMola-Caminal, MarinaVives-Bauza, CristófolNavarro, Rosa DíazTur, SilviaObach, VictorArenillas, Juan FranciscoSegura, TomásSerrano-Heras, GemmaMartí-Fàbregas, JoanDelgado-Mederos, RaquelFreijo-Guerrero, M MarMoniche, FranciscoCabezas, Juan AntonioCastellanos, MarGallego-Fabrega, CristinaGonzález-Sanchez, JonathanKrupinsky, JurekStrbian, DanielTatlisumak, TurgutThijs, VincentLemmens, RobinSlowik, AgnieszkaPera, JohannaKittner, StevenCole, JohnHeitsch, LauraIbañez, LauraCruchaga, CarlosLee, Jin-MooMontaner, JoanFernández-Cadenas, Israel2025-01-072025-01-072021https://hdl.handle.net/10668/27741Haemorrhagic transformation is a complication of recombinant tissue-plasminogen activator treatment. The most severe form, parenchymal haematoma, can result in neurological deterioration, disability, and death. Our objective was to identify single nucleotide variations associated with a risk of parenchymal haematoma following thrombolytic therapy in patients with acute ischaemic stroke. A fixed-effect genome-wide meta-analysis was performed combining two-stage genome-wide association studies (n = 1904). The discovery stage (three cohorts) comprised 1324 ischaemic stroke individuals, 5.4% of whom had a parenchymal haematoma. Genetic variants yielding a P-valueenGWASischaemic strokeparenchymal haematomapharmacogeneticsthrombolysisAgedAged, 80 and overCerebral HemorrhageFemaleFibrinolytic AgentsGenome-Wide Association StudyHumansIschemic StrokeMaleMiddle AgedPolymorphism, Single NucleotideThrombolytic TherapyTissue Plasminogen ActivatorTranscription FactorsTreatment Outcomeresearch article33723576open access10.1093/brain/awab0901460-2156PMC8418348https://academic.oup.com/brain/article-pdf/144/8/2416/40305952/awab090.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8418348/pdf